From ROME: take the A1 (direction Firenze), exit at Orte, then continue (direction Terni), Perugia; once you have reached Perugia take the E45 (direction Cesena) from the Umbertide exit, then continue straight on towards Gubbio, then Urbino.

From FIRENZE: take the A1 (direction ROME), exit Arezzo, then continue onwards on the E78 by Città di Castello; from here follow directions to Apecchio, Piobbico, Acqualagna, then take the Fano freeway up to the Urbino exit.

From BOLOGNA: take the A14 (direction Ancona), then the Pesaro-Urbino ext, then continue up to Urbino.

From ANCONA: take the A14 direction Bologna, exit to Fano then follow the direction Roma up to the turn-off for Urbino.